Gouglersville is a census-designated place in Spring, Cumru, and Brecknock townships, Berks County, Pennsylvania, United States. It is located at the intersection of Old Lancaster Pike, Vermont Road, Gouglersville Road, and Mohns Hill Road, a short distance east of an interchange from U.S. Route 222 and approximately 3.6 miles (5.8 km) from Mohnton. As of the 2010 census, the population was 548 residents.
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